How Wellbutrin Helps People Feel Well
When people think of antidepressants, they often think of medications like Prozac or Lexapro, which belong to a group called SSRIs. But there are other options that work differently and may be a better fit for certain patients. One of the most commonly prescribed alternatives is Wellbutrin (generic name: bupropion).
A Brief History
Wellbutrin was first approved by the U.S. Food and Drug Administration (FDA) in 1985. Over time, its safety profile was refined, and it has since become a widely trusted option in psychiatry. Today, Wellbutrin is available in several formulations, including immediate-release, sustained-release (SR), and extended-release (XL), which allow for flexibility in dosing.
FDA Approvals
Wellbutrin is FDA-approved for:
Major Depressive Disorder (MDD)
Seasonal Affective Disorder (SAD)
Additionally, a form of bupropion (marketed as Zyban) is approved to help people quit smoking.
Wellbutrin is prescribed off-label for ADHD.
How It Works
Unlike SSRIs, which primarily affect serotonin, Wellbutrin targets dopamine and norepinephrine. This different mechanism can make it helpful for patients who haven’t had success with other antidepressants or who experience certain side effects on SSRIs.
These neurotransmitters assist with focus and concentration as well.
Why I Prescribe It
I often consider Wellbutrin when:
A patient is struggling with depression, low energy, motivation, or concentration
Sexual side effects from SSRIs are a concern
There is a seasonal pattern to depression symptoms
A patient also wants support with smoking cessation
Anxiety and OCD are not present
Another advantage is that Wellbutrin is generally weight-neutral and less likely to cause sedation compared to some other antidepressants.
Important Considerations
Wellbutrin isn’t the right choice for everyone. It can increase the risk of seizures, so it’s not recommended for people with a history of seizures or certain eating disorders. It can also sometimes increase anxiety or insomnia, especially at higher doses.
Takeaway
Wellbutrin is a valuable option in the treatment of depression and related conditions. Its unique way of working means it can be a good alternative for patients who don’t tolerate or benefit from other antidepressants. If you’re considering treatment options for depression, talk with a psychiatrist about whether Wellbutrin may be a good fit for you.
