Lexapro (escitalopram) is one of the most widely prescribed antidepressants in psychiatry today.

Sertraline, widely known by its brand name Zoloft, is one of the most prescribed antidepressants in the U.S.

Prozac (fluoxetine) was the first selective serotonin reuptake inhibitor (SSRI) ever created. When it first became available in the late 1980s, it was hailed as a "miracle drug." While that might seem overstated now, at the time, it revolutionized how doctors treated depression and anxiety.